There is growing evidence that prenatal drug exposure results in abnormal structural
organization and vascular injury of the fetal brain (
Morrow et al 2001
,
Frank et al 1999
,
Mantovani and Calamandrei 2001
,
Mayes 1994
,
Smith et al 2001
,
Zuckerman and Brown 1993
). These drugs also appear to change the activity of neurons by altering the brain’s
neurochemistry (
Deutsch et al 1998
,
Heller et al 2001
,
Won et al 2002
,
Zachor et al 2000
). As the mechanisms underlying drug effects are beginning to be understood, their
impact on the drug-exposed infant is apparent, including a variety of neurobehaviors
not typically seen in other babies. Tremors, irritability, difficulty being consoled,
increased startle response, hypertonicity, poor tracking, lethargy, and decreased
interactive behavior have all been noted (
American Academy of Pediatrics Committee on Drugs 1998
,
Chasnoff and Griffith 1989
,
Eyler et al 2001
,
Frank et al 1998
,
Kosofsky 1998
,
Lewis 1991
,
Lewis et al 1989
).To read this article in full you will need to make a payment
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Further reading
- Longitudinal investigation of task persistence and sustained attention in children with prenatal cocaine exposure.Neurotoxicology and Teratology. 2001; 23: 545-559
- Intrauterine growth of full term infants.Pediatrics. 2001; 108: 1309-1319
Article info
Footnotes
☆The authors acknowledge support from Sigma Theta Tau International, Beta Gamma Chapter research award, for this research.
Identification
Copyright
© 2003 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
