We compared uropathogen antibiotic susceptibility across age groups of ambulatory
pediatric patients. For Escherichia coli (n = 5,099) and other Gram-negative rods (n = 626), significant differences (p < 0.05) existed across age groups for ampicillin, cefazolin, and trimethoprim/sulfamethoxazole
susceptibility. In E. coli, differences in trimethoprim/sulfamethoxazole susceptibility varied from 79% in children
under 2 to 88% in ages 16–18 (p < 0.001), while ampicillin susceptibility varied from 30% in children under 2 to 53%
in ages 2–5 (p = 0.015). Uropathogen susceptibility to common urinary anti-infectives may be lower
in the youngest children. Further investigation into these differences is needed to
facilitate appropriate and prudent treatment of urinary tract infections.
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Published online: October 02, 2013
Footnotes
1Portions of this work have been presented previously at the annual American Society of Health-system Pharmacists Midyear Clinical Meeting (Anaheim, CA. December 5–9, 2010).
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