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Review Article| Volume 62, e139-e147, January 2022

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Nursing interventions to reduce medication errors in paediatrics and neonates: Systematic review and meta-analysis

  • Takawira C. Marufu RN, BSc, MPH, PhD
    Takawira C. Marufu RN
    Correspondence
    Corresponding author at: Clinical Academic Lead Nursing Research, Nottingham Children's Hospital and Neonatology, Queens Medical Centre, C Floor South Block, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK.
    Contact
    Affiliations
    Nottingham Childrens Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK
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  • Rachel Bower RN, BSc, MSc
    Rachel Bower RN
      Affiliations
      Nottingham Childrens Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK
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    • Elizabeth Hendron, BSc
      Elizabeth Hendron
        Affiliations
        Library Services, Nottingham University Hospitals NHS Trust, Nottingham, UK
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      • Joseph C. Manning RN, MNursSci, PGCert, PhD
        Joseph C. Manning RN
          Affiliations
          Nottingham Childrens Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK

          Children and Young People Health Research, School of Health Sciences, University of Nottingham, Nottingham, UK
          Search for articles by this author
        Published:September 07, 2021DOI:https://doi.org/10.1016/j.pedn.2021.08.024
        Nursing interventions to reduce medication errors in paediatrics and neonates: Systematic review and meta-analysis
        Previous ArticleMotivational disposition towards psychological characteristics of israeli children with inflammatory bowel diseases: A case-control study
        Next ArticleParents' perception of health promotion: What do parents think of a healthy lifestyle in parenting and the impact of the school environment? A qualitative research in the Netherlands
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            Highlights

            • •
              Medication errors are multifacceted requring complex intervetion.
            • •
              Causes of errors need to be identified prior implementation of appropriate intervetions.
            • •
              Medication safety education is an integral element of interventions in a bid to reduce administration errors.
            • •
              Interdisciplinary collaboration in the medication process contributes to the reduction of medication administration errors

            Abstract

            Background

            Medication errors are a great concern to health care organisations as they are costly and pose a significant risk to patients. Children are three times more likely to be affected by medication errors than adults with medication administration error rates reported to be over 70%.

            Objective

            To identify nursing interventions to reduce medication administration errors and perform a meta-analysis.

            Methods

            Online databases; British Nursing Index (BNI), Cochrane Database of Systematic Reviews, Cumulative Index to Nursing and Allied Health Literature (CINAHL), EMBASE and MEDLINE were searched for relevant studies published between January 2000 to 2020. Studies with clear primary or secondary aims focusing on interventions to reduce medication administration errors in paediatrics, children and or neonates were included in the review.

            Results

            442 studies were screened and18 studies met the inclusion criteria. Seven interventions were identified from included studies; education programmes, medication information services, clinical pharmacist involvement, double checking, barriers to reduce interruptions during drug calculation and preparation, implementation of smart pumps and improvement strategies. Educational interventional aspects were the most common identified in 13 out of 18 included studies. Meta-analysis demonstrated an associated 64% reduction in medicine administration errors post intervention (pooled OR 0.36 (95% Confidence Interval (CI) 0.21–0.63) P = 0.0003).

            Conclusion

            Medication safety education is an important element of interventions to reduce administration errors. Medication errors are multifaceted that require a bundle interventional approach to address the complexities and dynamics relevant to the local context. It is imperative that causes of errors need to be identified prior to implementation of appropriate interventions.

            Keywords

            • Paediatrics
            • Neonates
            • Medication
            • Errors
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            Article info

            Publication history

            Published online: September 07, 2021
            Accepted: August 27, 2021
            Received in revised form: August 26, 2021
            Received: May 28, 2021

            Identification

            DOI: https://doi.org/10.1016/j.pedn.2021.08.024

            Copyright

            © 2021 Elsevier Inc. All rights reserved.

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