Abstract
Purpose
To validate a simplified Chinese version of the therapy-related symptom checklist
for children (TRSC-C) in children with cancer.
Methods
Reliability was assessed by internal consistency and test-retest coefficients. Dimensionality
and construct validity were clarified using exploratory factor analysis (EFA) and
confirmatory factor analysis (CFA). Pearson's correlation coefficient was calculated
between the TRSC-C and the PedsQL 3.0 cancer model (PedsQL 3.0) and the Lansky Play
Performance Scale (LPPS) to test concurrent validity. A Student's t-test was used to compare the scores of the simplified Chinese version of the TRSC-C
subscales by gender, age groups, and functional status to test sensitivity of the
TRSC-C.
Results
A sample of 170 children with cancer was recruited (11.27 ± 2.31 years). Cronbach's
alpha (0.89) and interclass correlation coefficient (0.98) were acceptable. Seven
factors with eigenvalues >1 explained 56.86% of the total variances. CFA demonstrated
an acceptable model (CFI = 0.93, RMSE = 0.04). Concurrent validity was supported by
moderate to high correlations between the TRSC-C and both the PedsQL 3.0 (r = −0.71) and LPPS (r = −0.43). The TRSC-C scores significantly differed by age groups and functional status
(effect size 0.40–0.93), indicating adequate sensitivity.
Conclusion
The simplified Chinese version of the TRSC-C demonstrated acceptable reliability,
validity, and sensitivity to support its use in clinical practice and future studies.
Keywords
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Article info
Publication history
Published online: January 28, 2022
Accepted:
January 13,
2022
Received in revised form:
January 12,
2022
Received:
August 17,
2021
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
