Highlights
- •Chemotherapy-induced nausea and vomiting (CINV) impacts quality of life.
- •Reviews pediatric-specific recommendations for monitoring and pharmacotherapy for CINV.
- •Shares antiemetic algorithm and experience from our institution.
Abstract
Chemotherapy-induced nausea and vomiting (CINV) is a common side effect of most chemotherapy
agents. Suboptimal management of CINV impacts quality of life, nutrition, gastrointestinal
(GI) integrity, and adherence to chemotherapy treatment plans. This article reviews
the principles of CINV management, planning and implementation of antiemetic regimens,
and pharmacology of the antiemetics currently available in the United States appropriate
for pediatric use. With the advent of more targeted therapies, increased use of immunotherapy,
and the effects of radiotherapy to the brain, spine, and abdomen, treatment of CINV
now has a broader application than just for chemotherapeutics alone.
Keywords
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Article info
Publication history
Published online: June 24, 2022
Accepted:
June 11,
2022
Received in revised form:
May 30,
2022
Received:
February 1,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
